Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport

The COOH-terminal tail of mammalian neurofilament heavy subunit (NF-H), the largest neurofilament subunit, contains 44-51 lysine–serine–proline repeats that are nearly stoichiometrically phosphorylated after assembly into neurofilaments in axons. Phosphorylation of these repeats has been implicated...

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Auteurs principaux: Rao, Mala V., Garcia, Michael L., Miyazaki, Yukio, Gotow, Takahiro, Yuan, Aidong, Mattina, Salvatore, Ward, Chris M., Calcutt, Nigel A., Uchiyama, Yasuo, Nixon, Ralph A., Cleveland, Don W.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2002
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174004/
https://ncbi.nlm.nih.gov/pubmed/12186852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202037
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