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Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS

Eliminating assembled neurofilaments (NFs) from axons or misaccumulating NFs in motor neuron cell bodies strongly slows disease in mouse models of mutant superoxide dismutase 1 (SOD1)-induced amyotrophic lateral sclerosis. One proposal for how reducing axonal NFs can increase survival is that the mu...

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Detalhes bibliográficos
Main Authors: Lobsiger, Christian S., Garcia, Michael L., Ward, Christopher M., Cleveland, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177385/
https://ncbi.nlm.nih.gov/pubmed/16002469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503862102
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