Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex

Internalization of β-adrenergic receptors (βARs) occurs by the sequential binding of β-arrestin, the clathrin adaptor AP-2, and clathrin. D-3 phosphoinositides, generated by the action of phosphoinositide 3-kinase (PI3K) may regulate the endocytic process; however, the precise molecular mechanism is...

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Hlavní autoři: Naga Prasad, Sathyamangla V., Laporte, Stéphane A., Chamberlain, Dean, Caron, Marc G., Barak, Larry, Rockman, Howard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2002
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173831/
https://ncbi.nlm.nih.gov/pubmed/12163475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200202113
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