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Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

Although the transport of model proteins across the mammalian ER can be reconstituted with purified Sec61p complex, TRAM, and signal recognition particle receptor, some substrates, such as the prion protein (PrP), are inefficiently or improperly translocated using only these components. Here, we pur...

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Detalles Bibliográficos
Autores principales: Fons, Ryen D., Bogert, Brigitte A., Hegde, Ramanujan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173754/
https://ncbi.nlm.nih.gov/pubmed/12578908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210095
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