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Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

Although the transport of model proteins across the mammalian ER can be reconstituted with purified Sec61p complex, TRAM, and signal recognition particle receptor, some substrates, such as the prion protein (PrP), are inefficiently or improperly translocated using only these components. Here, we pur...

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Bibliographic Details
Main Authors: Fons, Ryen D., Bogert, Brigitte A., Hegde, Ramanujan S.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173754/
https://ncbi.nlm.nih.gov/pubmed/12578908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210095
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