Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptor is also required for the above responses. We no...

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Detalhes bibliográficos
Main Authors: Bisogno, Tiziana, Howell, Fiona, Williams, Gareth, Minassi, Alberto, Cascio, Maria Grazia, Ligresti, Alessia, Matias, Isabel, Schiano-Moriello, Aniello, Paul, Praveen, Williams, Emma-Jane, Gangadharan, Uma, Hobbs, Carl, Di Marzo, Vincenzo, Doherty, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173631/
https://ncbi.nlm.nih.gov/pubmed/14610053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200305129
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