Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

The p16(INK4a) (p16) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including lung cancer, the leading cause of cancer-related deaths in the U.S. We have determined the timing of this event in an animal model of lung carcinogenesis and in human squam...

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Bibliografski detalji
Glavni autori: Belinsky, Steven A., Nikula, Kristen J., Palmisano, William A., Michels, Ruth, Saccomanno, Geno, Gabrielson, Edward, Baylin, Stephen B., Herman, James G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21736/
https://ncbi.nlm.nih.gov/pubmed/9751761
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