Frequent aberrant methylation of p16INK4a in primary rat lung tumors.

The p16INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous deletion or methylation of the 5' CpG island in cell lines derived from human non-small-cell lung cancers. However, the frequency of dysfunction in primary tumors appears to be significantly lower than that in cell...

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Hauptverfasser: Swafford, D S, Middleton, S K, Palmisano, W A, Nikula, K J, Tesfaigzi, J, Baylin, S B, Herman, J G, Belinsky, S A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC231861/
https://ncbi.nlm.nih.gov/pubmed/9032263
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