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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

Progress through mitosis is controlled by the sequential destruction of key regulators including the mitotic cyclins and securin, an inhibitor of anaphase whose destruction is required for sister chromatid separation. Here we have used live cell imaging to determine the exact time when human securin...

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Bibliografske podrobnosti
Main Authors: Hagting, Anja, den Elzen, Nicole, Vodermaier, Hartmut C., Waizenegger, Irene C., Peters, Jan-Michael, Pines, Jonathon
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173548/
https://ncbi.nlm.nih.gov/pubmed/12070128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200111001
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