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Huntingtin forms toxic NH(2)-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
Although NH(2)-terminal mutant huntingtin (htt) fragments cause neurological disorders in Huntington's disease (HD), it is unclear how toxic htt fragments are generated and contribute to the disease process. Here, we report that complex NH(2)-terminal mutant htt fragments smaller than the first...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173440/ https://ncbi.nlm.nih.gov/pubmed/14557250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200306038 |
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