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Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1
The toxic effect of cholera toxin (CT) on target cells is caused by its A1 chain. This polypeptide is released from the holotoxin and unfolded in the lumen of the ER by the action of protein disulfide isomerase (PDI), before being retrotranslocated into the cytosol. The polypeptide is initially unfo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173060/ https://ncbi.nlm.nih.gov/pubmed/12403808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200207120 |
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