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Protein-disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from the Holotoxin without Unfolding the A1 Subunit

Protein-disulfide isomerase (PDI) has been proposed to exhibit an “unfoldase” activity against the catalytic A1 subunit of cholera toxin (CT). Unfolding of the CTA1 subunit is thought to displace it from the CT holotoxin and to prepare it for translocation to the cytosol. To date, the unfoldase acti...

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Detalhes bibliográficos
Main Authors: Taylor, Michael, Banerjee, Tuhina, Ray, Supriyo, Tatulian, Suren A., Teter, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121353/
https://ncbi.nlm.nih.gov/pubmed/21543321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237966
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