A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit.

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H Pande, Suren A Tatulian, Ken Teter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-04-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3079739?pdf=render
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados