A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality...

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Main Authors: Taylor, Michael, Banerjee, Tuhina, Navarro-Garcia, Fernando, Huerta, Jazmin, Massey, Shane, Burlingame, Mansfield, Pande, Abhay H., Tatulian, Suren A., Teter, Ken
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079739/
https://ncbi.nlm.nih.gov/pubmed/21526142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018825
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