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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting...

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Detalhes bibliográficos
Main Authors: Hauf, Silke, Cole, Richard W., LaTerra, Sabrina, Zimmer, Christine, Schnapp, Gisela, Walter, Rainer, Heckel, Armin, van Meel, Jacques, Rieder, Conly L., Peters, Jan-Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172906/
https://ncbi.nlm.nih.gov/pubmed/12707311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208092
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