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A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivity to granzyme B–mediated apoptosis. On this basis, it has been proposed that cells lacking MPR are poor...

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Bibliografske podrobnosti
Main Authors: Trapani, Joseph A., Sutton, Vivien R., Thia, Kevin Y.T., Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172645/
https://ncbi.nlm.nih.gov/pubmed/12538642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210150
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