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Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import

Ubiquitin is a small polypeptide that is conjugated to proteins and commonly serves as a degradation signal. The attachment of ubiquitin (Ub) to a substrate proceeds through a multi-enzyme cascade involving an activating enzyme (E1), a conjugating enzyme (E2), and a protein ligase (E3). We previousl...

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Autors principals: Plafker, Scott M., Plafker, Kendra S., Weissman, Allan M., Macara, Ian G.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172591/
https://ncbi.nlm.nih.gov/pubmed/15545318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406001
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