Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung

Disruption of latent TGF-β binding protein (LTBP)–4 expression in the mouse leads to abnormal lung development and colorectal cancer. Lung fibroblasts from these mice produced decreased amounts of active TGF-β, whereas secretion of latent TGF-β was significantly increased. Expression and secretion o...

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Bibliografische gegevens
Hoofdauteurs: Koli, Katri, Wempe, Frank, Sterner-Kock, Anja, Kantola, Anna, Komor, Martina, Hofmann, Wolf-K., von Melchner, Harald, Keski-Oja, Jorma
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2004
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172518/
https://ncbi.nlm.nih.gov/pubmed/15466481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403067
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