Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8(+) T cells from mice deficient in per...

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Detalhes bibliográficos
Main Authors: Pardo, Julián, Bosque, Alberto, Brehm, Reina, Wallich, Reinhard, Naval, Javier, Müllbacher, Arno, Anel, Alberto, Simon, Markus M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172484/
https://ncbi.nlm.nih.gov/pubmed/15534000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406115
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