MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells

Tumor cells have a tendency to use glucose fermentation to obtain energy instead of mitochondrial oxidative phosphorylation (OXPHOS). We demonstrated that this phenotype correlated with loss of ERK5 expression and with reduced MHC class I expression. Consequently, tumor cells could evade cytotoxic T...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Catalán, Elena, Charni, Seyma, Jaime, Paula, Aguiló, Juan Ignacio, Enríquez, José Antonio, Naval, Javier, Pardo, Julián, Villalba, Martín, Anel, Alberto
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368123/
https://ncbi.nlm.nih.gov/pubmed/25949869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.985924
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