Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1–derived O-glycans

The core 1 β1-3-galactosyltransferase (T-synthase) transfers Gal from UDP-Gal to GalNAcα1-Ser/Thr (Tn antigen) to form the core 1 O-glycan Galβ1-3GalNAcα1-Ser/Thr (T antigen). The T antigen is a precursor for extended and branched O-glycans of largely unknown function. We found that wild-type mice e...

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Main Authors: Xia, Lijun, Ju, Tongzhong, Westmuckett, Andrew, An, Guangyu, Ivanciu, Lacramioara, McDaniel, J. Michael, Lupu, Florea, Cummings, Richard D., McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172228/
https://ncbi.nlm.nih.gov/pubmed/14745002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200311112
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