Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin

During early embryonic development in mammals, including humans and mice, megakaryocytes (Mks) first originate from primitive hematopoiesis in the yolk sac. These embryonic Mks (eMks) circulate in the vasculature with unclear function. Herein, we report that podoplanin (PDPN), the ligand of C-type l...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Hoover, Christopher, Kondo, Yuji, Shao, Bojing, McDaniel, Michael J., Lee, Robert, McGee, Samuel, Whiteheart, Sidney, Bergmeier, Wolfgang, McEver, Rodger P., Xia, Lijun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138551/
https://ncbi.nlm.nih.gov/pubmed/33619517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020010310
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