Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin

During early embryonic development in mammals, including humans and mice, megakaryocytes (Mks) first originate from primitive hematopoiesis in the yolk sac. These embryonic Mks (eMks) circulate in the vasculature with unclear function. Herein, we report that podoplanin (PDPN), the ligand of C-type l...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Hoover, Christopher, Kondo, Yuji, Shao, Bojing, McDaniel, Michael J., Lee, Robert, McGee, Samuel, Whiteheart, Sidney, Bergmeier, Wolfgang, McEver, Rodger P., Xia, Lijun
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138551/
https://ncbi.nlm.nih.gov/pubmed/33619517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020010310
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