Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin

During early embryonic development in mammals, including humans and mice, megakaryocytes (Mks) first originate from primitive hematopoiesis in the yolk sac. These embryonic Mks (eMks) circulate in the vasculature with unclear function. Herein, we report that podoplanin (PDPN), the ligand of C-type l...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hoover, Christopher, Kondo, Yuji, Shao, Bojing, McDaniel, Michael J., Lee, Robert, McGee, Samuel, Whiteheart, Sidney, Bergmeier, Wolfgang, McEver, Rodger P., Xia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138551/
https://ncbi.nlm.nih.gov/pubmed/33619517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020010310
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