Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

Biochemical experiments have shown that Smad6 and Smad ubiquitin regulatory factor 1 (Smurf1) block the signal transduction of bone morphogenetic proteins (BMPs). However, their in vivo functions are largely unknown. Here, we generated transgenic mice overexpressing Smad6 in chondrocytes. Smad6 tran...

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Hlavní autoři: Horiki, Mitsuru, Imamura, Takeshi, Okamoto, Mina, Hayashi, Makoto, Murai, Junko, Myoui, Akira, Ochi, Takahiro, Miyazono, Kohei, Yoshikawa, Hideki, Tsumaki, Noriyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172180/
https://ncbi.nlm.nih.gov/pubmed/15123739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200311015
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