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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

Misfolded proteins retained in the endoplasmic reticulum (ER) are degraded by the ER-associated degradation pathway. The mechanisms used to sort them from correctly folded proteins remain unclear. Analysis of substrates with defined folded and misfolded domains has revealed a system of sequential ch...

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Detalhes bibliográficos
Main Authors: Vashist, Shilpa, Ng, Davis T.W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172089/
https://ncbi.nlm.nih.gov/pubmed/15078901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309132
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