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Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59(fyn) and to enhance neurite outgrowth

In spite of advances in understanding the role of the cellular prion protein (PrP) in neural cell interactions, the mechanisms of PrP function remain poorly characterized. We show that PrP interacts directly with the neural cell adhesion molecule (NCAM) and associates with NCAM at the neuronal cell...

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Hlavní autoři: Santuccione, Antonella, Sytnyk, Vladimir, Leshchyns'ka, Iryna, Schachner, Melitta
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171870/
https://ncbi.nlm.nih.gov/pubmed/15851519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409127
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