Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

Mutations in the AAA adenosine triphosphatase (ATPase) Spastin (SPG4) cause an autosomal dominant form of hereditary spastic paraplegia, which is a retrograde axonopathy primarily characterized pathologically by the degeneration of long spinal neurons in the corticospinal tracts and the dorsal colum...

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Bibliografiska uppgifter
Huvudupphovsmän: Evans, Katia J., Gomes, Edgar R., Reisenweber, Steven M., Gundersen, Gregg G., Lauring, Brett P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2005
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171748/
https://ncbi.nlm.nih.gov/pubmed/15716377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409058
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