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Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
Mutations in the AAA adenosine triphosphatase (ATPase) Spastin (SPG4) cause an autosomal dominant form of hereditary spastic paraplegia, which is a retrograde axonopathy primarily characterized pathologically by the degeneration of long spinal neurons in the corticospinal tracts and the dorsal colum...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171748/ https://ncbi.nlm.nih.gov/pubmed/15716377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409058 |
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