A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for ∼20–25% of familial ALS cases, and transgenic...

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Autori principali: Kieran, Dairin, Hafezparast, Majid, Bohnert, Stephanie, Dick, James R.T., Martin, Joanne, Schiavo, Giampietro, Fisher, Elizabeth M.C., Greensmith, Linda
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2005
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171702/
https://ncbi.nlm.nih.gov/pubmed/15911875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200501085
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