A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for ∼20–25% of familial ALS cases, and transgenic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kieran, Dairin, Hafezparast, Majid, Bohnert, Stephanie, Dick, James R.T., Martin, Joanne, Schiavo, Giampietro, Fisher, Elizabeth M.C., Greensmith, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171702/
https://ncbi.nlm.nih.gov/pubmed/15911875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200501085
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados