Deficits in axonal transport precede ALS symptoms in vivo

ALS is a fatal neurodegenerative disease characterized by selective motor neuron death resulting in muscle paralysis. Mutations in superoxide dismutase 1 (SOD1) are responsible for a subset of familial cases of ALS. Although evidence from transgenic mice expressing human mutant SOD1(G93A) suggests t...

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Detalles Bibliográficos
Autores principales: Bilsland, Lynsey G., Sahai, Erik, Kelly, Gavin, Golding, Matthew, Greensmith, Linda, Schiavo, Giampietro
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996651/
https://ncbi.nlm.nih.gov/pubmed/21059924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006869107
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