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p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
Cell cycle progression is negatively regulated by the pocket proteins pRb, p107, and p130. However, the mechanisms responsible for this inhibition are not fully understood. Here, we show that overexpression of p107 in fibroblasts inhibits Cdk2 activation and delays S phase entry. The inhibition of C...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171673/ https://ncbi.nlm.nih.gov/pubmed/15631990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404146 |
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