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p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

Cell cycle progression is negatively regulated by the pocket proteins pRb, p107, and p130. However, the mechanisms responsible for this inhibition are not fully understood. Here, we show that overexpression of p107 in fibroblasts inhibits Cdk2 activation and delays S phase entry. The inhibition of C...

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Detalhes bibliográficos
Main Authors: Rodier, Geneviève, Makris, Constantin, Coulombe, Philippe, Scime, Anthony, Nakayama, Keiko, Nakayama, Keiichi I., Meloche, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171673/
https://ncbi.nlm.nih.gov/pubmed/15631990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404146
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