p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

Cell cycle progression is negatively regulated by the pocket proteins pRb, p107, and p130. However, the mechanisms responsible for this inhibition are not fully understood. Here, we show that overexpression of p107 in fibroblasts inhibits Cdk2 activation and delays S phase entry. The inhibition of C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rodier, Geneviève, Makris, Constantin, Coulombe, Philippe, Scime, Anthony, Nakayama, Keiko, Nakayama, Keiichi I., Meloche, Sylvain
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2005
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171673/
https://ncbi.nlm.nih.gov/pubmed/15631990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404146
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