Structural properties and neuronal toxicity of amyotrophic lateral sclerosis–associated Cu/Zn superoxide dismutase 1 aggregates

The appearance of protein aggregates is a characteristic of protein misfolding disorders including familial amyotrophic lateral sclerosis, a neurodegenerative disease caused by inherited mutations in Cu/Zn superoxide dismutase 1 (SOD1). Here, we use live cell imaging of neuronal and nonneuronal cell...

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Autors principals: Matsumoto, Gen, Stojanovic, Aleksandar, Holmberg, Carina I., Kim, Soojin, Morimoto, Richard I.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171239/
https://ncbi.nlm.nih.gov/pubmed/16216923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504050
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