NHE3 inhibition by cAMP and Ca(2+) is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes

The PDZ-binding protein PDZK1 (NHERF3/CAP70/PDZ-dc-1) in vitro binds to NHE3, but its role in the regulation of NHE3 activity in native enterocytes is unknown. This study was undertaken to understand the physiological role of PDZK1 in regulating NHE3 activity in native murine colonic enterocytes. NH...

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Detalhes bibliográficos
Main Authors: Cinar, Ayhan, Chen, Mingmin, Riederer, Brigitte, Bachmann, Oliver, Wiemann, Martin, Manns, Michael, Kocher, Olivier, Seidler, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Alimentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170846/
https://ncbi.nlm.nih.gov/pubmed/17395628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.131722
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