IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes

Background: The PDZ adaptor protein PDZK1 modulates the membrane expression and function of a variety of intestinal receptors and ion/nutrient transporters. Its expression is strongly decreased in inflamed intestinal mucosa of mice and IBD patients. Aim and Methods: We investigated whether the infla...

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Bibliografiske detaljer
Udgivet i:Front Physiol
Main Authors: Luo, Min, Yeruva, Sunil, Liu, Yongjian, Chodisetti, Giriprakash, Riederer, Brigitte, Menon, Manoj B., Tachibana, Keisuke, Doi, Takefumi, Seidler, Ursula E.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293818/
https://ncbi.nlm.nih.gov/pubmed/28223944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00061
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