Evidence for a causal link between adaptor protein PDZK1 downregulation and Na(+)/H(+) exchanger NHE3 dysfunction in human and murine colitis

A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We previously reported a strong decrease in the NHERF family member PDZK1 (NHERF3), which binds to NHE3 and regulates its function in a mouse model...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Yeruva, Sunil, Chodisetti, Giriprakash, Luo, Min, Chen, Mingmin, Cinar, Ayhan, Ludolph, Lisa, Lünnemann, Maria, Goldstein, Julia, Singh, Anurag Kumar, Riederer, Brigitte, Bachmann, Oliver, Bleich, Andre, Gereke, Markus, Bruder, Dunja, Hagen, Susan, He, Peijian, Yun, Chris, Seidler, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Molecular and Cellular Mechanisms of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383727/
https://ncbi.nlm.nih.gov/pubmed/25271043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-014-1608-x
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