Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks

Protrusion of the leading edge of migrating epithelial cells requires precise regulation of two actin filament (F-actin) networks, the lamellipodium and lamella. Cofilin is a downstream target of Rho-GTPase signaling that promotes F-actin cycling through its F-actin nucleating, severing and depolyme...

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Autores principales: Delorme, Violaine, Machacek, Matthias, DerMardirossian, Celine, Anderson, Karen L., Wittmann, Torsten, Hanein, Dorit, Waterman-Storer, Clare, Danuser, Gaudenz, Bokoch, Gary M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170459/
https://ncbi.nlm.nih.gov/pubmed/17981134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.08.011
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