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Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks
Protrusion of the leading edge of migrating epithelial cells requires precise regulation of two actin filament (F-actin) networks, the lamellipodium and lamella. Cofilin is a downstream target of Rho-GTPase signaling that promotes F-actin cycling through its F-actin nucleating, severing and depolyme...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2170459/ https://ncbi.nlm.nih.gov/pubmed/17981134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2007.08.011 |
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