Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior

Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1 induces an epithelial-like morphology with functio...

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Bibliografiska uppgifter
Huvudupphovsmän: Sander, Eva E., ten Klooster, Jean P., van Delft, Sanne, van der Kammen, Rob A., Collard, John G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 1999
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169355/
https://ncbi.nlm.nih.gov/pubmed/10579721
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