Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

We previously demonstrated that both Tiam1, an activator of Rac, and constitutively active V12Rac promote E-cadherin–mediated cell–cell adhesion in epithelial Madin Darby canine kidney (MDCK) cells. Moreover, Tiam1 and V12Rac inhibit invasion of Ras-transformed, fibroblastoid MDCK-f3 cells by restor...

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Hauptverfasser: Sander, Eva E., van Delft, Sanne, ten Klooster, Jean P., Reid, Tim, van der Kammen, Rob A., Michiels, Frits, Collard, John G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1998
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133078/
https://ncbi.nlm.nih.gov/pubmed/9832565
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