Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

The Rac-specific GEF (guanine-nucleotide exchange factor) Tiam1 (T-lymphoma invasion and metastasis 1) regulates migration, cell–matrix and cell–cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Using yeast two-hybrid screening and biochemical assays, we found that Tiam1 i...

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Autori principali: ten Klooster, Jean Paul, Evers, Eva E., Janssen, Lennert, Machesky, Laura M., Michiels, Frits, Hordijk, Peter, Collard, John G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479755/
https://ncbi.nlm.nih.gov/pubmed/16599904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051957
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