Identification of an APOBEC3G Binding Site in Human Immunodeficiency Virus Type 1 Vif and Inhibitors of Vif-APOBEC3G Binding

The APOBEC3 cytidine deaminases are potent antiviral factors that restrict replication of human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin ligase with cullin 5 and elongins B and C. The N-termi...

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Bibliographic Details
Main Authors: Mehle, Andrew, Wilson, Heather, Zhang, Chengsheng, Brazier, Andrew Jay, McPike, Mark, Pery, Erez, Gabuzda, Dana
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169136/
https://ncbi.nlm.nih.gov/pubmed/17898068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00204-07
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