Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation

The initiation factor eukaryotic translation initiation factor 4E (eIF4E) plays a critical role in initiating translation of mRNAs, including those encoding oncogenic proteins. Therefore, eIF4E is considered a survival protein involved in cell cycle progression, cell transformation, and apoptotic re...

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Autores principales: Wang, Xuerong, Yue, Ping, Chan, Chi-Bun, Ye, Keqiang, Ueda, Takeshi, Watanabe-Fukunaga, Rie, Fukunaga, Rikiro, Fu, Haian, Khuri, Fadlo R., Sun, Shi-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2007
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169067/
https://ncbi.nlm.nih.gov/pubmed/17724079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00760-07
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