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An Intronic Locus Control Region Plays an Essential Role in the Establishment of an Autonomous Hepatic Chromatin Domain for the Human Vitamin D-Binding Protein Gene

The human vitamin D-binding protein (hDBP) gene exists in a cluster of four liver-expressed genes. A minimal hDBP transgene, containing a defined set of liver-specific DNase I hypersensitive sites (HSs), is robustly expressed in mouse liver in a copy-number-dependent manner. Here we evaluate these H...

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Autors principals: Hiroki, Tomoko, Liebhaber, Stephen A., Cooke, Nancy E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169047/
https://ncbi.nlm.nih.gov/pubmed/17785430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00331-07
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