Selection and Analysis of Mutations in an Encephalomyocarditis Virus Internal Ribosome Entry Site That Improve the Efficiency of a Bicistronic Flavivirus Construct

Flaviviruses have a positive-stranded RNA genome, which simultaneously serves as an mRNA for translation of the viral proteins. All of the structural and nonstructural proteins are translated from a cap-dependent cistron as a single polyprotein precursor. In an earlier study (K. K. Orlinger, V. M. H...

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Autori principali: Orlinger, Klaus K., Kofler, Regina M., Heinz, Franz X., Hoenninger, Verena M., Mandl, Christian W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2007
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168969/
https://ncbi.nlm.nih.gov/pubmed/17855533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01017-07
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