Flavin-Dependent Thymidylate Synthase ThyX Activity: Implications for the Folate Cycle in Bacteria

Although flavin-dependent ThyX proteins show thymidylate synthase activity in vitro and functionally complement thyA defects in heterologous systems, direct proof of their cellular functions is missing. Using insertional mutagenesis of Rhodobacter capsulatus thyX, we constructed the first defined th...

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Main Authors: Leduc, Damien, Escartin, Frédéric, Nijhout, H. Frederik, Reed, Michael C., Liebl, Ursula, Skouloubris, Stéphane, Myllykallio, Hannu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Enzymes and Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168944/
https://ncbi.nlm.nih.gov/pubmed/17890305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01380-07
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