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Development of a Challenge-Protective Vaccine Concept by Modification of the Viral RNA-Dependent RNA Polymerase of Canine Distemper Virus

We demonstrate that insertion of the open reading frame of enhanced green fluorescent protein (EGFP) into the coding sequence for the second hinge region of the viral L (large) protein (RNA-dependent RNA polymerase) attenuates a wild-type canine distemper virus. Moreover, we show that single intrana...

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Autores principales: Silin, D., Lyubomska, O., Ludlow, M., Duprex, W. P., Rima, B. K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168841/
https://ncbi.nlm.nih.gov/pubmed/17898047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01385-07
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