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Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance

Several isoforms of neuronal nitric oxide synthase (nNOS) have been identified. Antisense approaches have been developed which can selectively down-regulate nNOS-1, which corresponds to the full-length nNOS originally cloned from the brain, and nNOS-2, a truncated form lacking two exons which is gen...

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Detalhes bibliográficos
Main Authors: Kolesnikov, Yuri A., Pan, Ying-Xian, Babey, Anna-Marie, Jain, Subash, Wilson, Roger, Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21584/
https://ncbi.nlm.nih.gov/pubmed/9223342
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