Modifying L-Type Calcium Current Kinetics: Consequences for Cardiac Excitation and Arrhythmia Dynamics

The L-type Ca current (I(Ca,L)), essential for normal cardiac function, also regulates dynamic action potential (AP) properties that promote ventricular fibrillation. Blocking I(Ca,L) can prevent ventricular fibrillation, but only at levels suppressing contractility. We speculated that, instead of b...

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Hlavní autoři: Mahajan, Aman, Sato, Daisuke, Shiferaw, Yohannes, Baher, Ali, Xie, Lai-Hua, Peralta, Robert, Olcese, Riccardo, Garfinkel, Alan, Qu, Zhilin, Weiss, James N.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2008
Témata:
Biophysical Theory and Modeling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157257/
https://ncbi.nlm.nih.gov/pubmed/18160661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.98590
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